Hematologic and cytogenetic biomarkers of leukemia risk from formaldehyde exposure
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چکیده
منابع مشابه
Cytogenetic effects of formaldehyde exposure in students of mortuary science.
The effect of low-level exposure to formaldehyde on oral, nasal, and lymphoycte biological markers was studied prospectively in a group of 29 mortician students who were about to take a course in embalming. During the 85-day study period, the subjects performed an average of 6.9 embalmings and had average cumulative formaldehyde exposures of 14.8 ppm-h, with an average air concentration of 1.4 ...
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Conventional cytogenetic analysis of chromosome abnormalities in hematologic malignancies is hampered by the low mitotic index and poor quality of metaphases. A range of techniques based on fluorescence in situ hybridization (FISH) has greatly enhanced the identification of non-random translocations and deletions, pinpointing regions which contain genes involved in leukemogenesis. One of the ma...
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Background: Imatinib mesylate (IM), a strong and selective tyrosine kinase inhibitor, has been approved as the front line of treatment in chronic myeloid leukemia (CML) patients. In spite of satisfactory results of imatinib in the treatment of patients with CML, patients with treatment failure or suboptimal response developed resistance that might be because of pharmacogenetic variants. This st...
متن کاملEvaluation of Awareness, Performance and Side Effects of Formaldehyde Exposure
Background and purpose: Formaldehyde is used in operating rooms to disinfect and sterilize surgical instruments. Inhalation of formaldehyde gas causes various respiratory complications in people. Awareness on the use of formaldehyde can prevent many complications. This study was conducted to determine the level of knowledge and practice about formaldehyde exposure in the staff and students of t...
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BACKGROUND The prognostic value of cytogenetic findings in chronic myelomonocytic leukemia is unclear. Our purpose was to evaluate the independent prognostic impact of cytogenetic abnormalities in a large series of patients with chronic myelomonocytic leukemia included in the database of the Spanish Registry of Myelodysplastic Syndromes. DESIGN AND METHODS We studied 414 patients with chronic...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2017
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgx072